Dose-dependent effects of simvastatin, atorvastatin and rosuvastatin on apoptosis and inflammation pathways on cancerous lung cells

The aim of study was to investigate the anti-proliferative and inflammatory effects atorvastatin, rosuvastatin, simvastatin in lung cancer. statins were investigated Vero, BEAS-2B, A549 cell lines. In addition expressions BAX, BCL-2, TNFα, IL-10, IL-6, protein levels IL-6 determined. Cell viability MDA also measured. While numbers groups with low doses found be approximately 1x106/mL, proliferation inhibited at higher rates containing high doses. Simvastatin, dose atorvastatin upregulated while both rosuvastatin caused downregulation BCL-2. All statin had MDA. Simvastatin TNFα. a rosuvastatin. TNFα groups. IL-10 highest Atorvastatin lower IL-6. Although have been reduced by all statins, is more effective on studied genes.